The study includes questionnaires, clinical assessment and biomarkers. Risk of venous thromboembolism and myocardial infarction. Nonfasting triglycerides and risk of myocardial infarction. The copenhagen general population study n 56 960 is a prospective study initiated in 2003,20 and the copenhagen city heart study n 9041 is a prospective study initiated in 1976. Methods study design and participants we included 5578 individuals aged 20100 years from the second examination of the copenhagen general population study cgps, a population based prospective cohort study initiated in april 2014 with ongoing enrolment. Coronary artery calcium assessed with calibrated mass. Increasedriskforothercancersinadditiontobreastcancer for. We tested the hypothesis that high tobacco consumption is causally associated with low body weight. Healthy lifestyles reduce supar and mortality in a danish. We recorded blood eosinophils at baseline and future copd exacerbations longitudinally, defined as moderate shortcourse treatment of systemic corticosteroids or severe hospitalization. In this study the population sample was also a stratified, family cluster design.
Conflicting evidence has been found regarding the association between high tobacco consumption and body weight among smokers. In this questionnaire we will ask you to answer some questions about your health and lifestyle. Total mortality by transferrin saturation levels oxford academic. Increased risk for other cancers in addition to breast. Obese individuals experience wheezing without asthma but not asthma without wheezing. Bg medicine today announced that it has entered into a research collaboration agreement with the copenhagen general population study with the goals to discover and validate novel cardiovascular biomarkers, including those. Prevalence, characteristics, and prognosis of early. Eligibility and preventive potential for new evidence. The copenhagen general population study atherosclerosis. Prognosis of asymptomatic and symptomatic, undiagnosed copd. The copenhagen city heart study, also known as osterbroundersogelsen, is a large prospective cardiovascular population study of 20,000 women and men that was launched in 1975 by dr peter schnohr and dr gorm jensen together with statistician jorgen nyboe and prof. Among 81,668 individuals in the copenhagen general population study, we examined 7,225 with copd based on spirometry. Nov 18, 2014 objective to test the hypothesis that genetically low 25hydroxyvitamin d concentrations are associated with increased mortality. Seroepidemiology of pertussis in a crosssectional study.
The authors have reported that they have no relationships relevant to the contents of this paper to disclose. Bg medicine and copenhagen general population study. We identified and ranked chronic cough risk factors at the individual and community level using data from 14,669 individuals from the copenhagen general population study. Among 81,668 individuals from the copenhagen general population study, we examined 7,225 with copd based on spirometry. Copenhagen general population study the british journal of. Majority of neversmokers with airflow limitation do not have. Combined effect of pnpla3, tm6sf2, and hsd17b variants. Mar 19, 2020 the copenhagen general population study, herlev and gentofte hospital, herlev, denmark.
The cgps is an ongoing prospective cohort study of the danish general population. A total of 58527 individuals from the cgps had baseline measurements of lpa. It was initiated in 2003 and recruitment is ongoing. We recorded blood eosinophils at baseline and future copd exacerbations longitudinally, defined as moderate shortcourse treatment with systemic corticosteroids or severe hospitalization. Major longlasting european studies of the general population this. Majority of neversmokers with airflow limitation do not. In the copenhagen general population study, the jak2 v617f mutation was detected by a pcrbased taqman screening assay identifying the 1% with the highest signal, these were subsequently tested with a highly sensitive realtime qpcr assay with a limit of detection of 0. Study design, participation and characteristics of the. Faculty of health and medical sciences, university of copenhagen, copenhagen, denmark. In the eclipse evaluation of copd longitudinally to identify predictive surrogate endpoints study cohort, only 37% of the patients with copd had persistently increased blood eosinophils at or above 2%. Arterial and venous thrombosis by high platelet count and. The copenhagen general population study documented that in a general population context among individuals with copd, blood eosinophil levels above 340 cells.
Combined value of exhaled nitric oxide and blood eosinophils. Prevalence, characteristics, and prognosis of early chronic. Obese individuals experience wheezing without asthma but. View the article pdf and any associated supplements and figures for a period of 48 hours. Furthermore, our study indicates the need for a multifaceted. News from the european atherosclerosis society congress. Characteristics and outcomes of chronic obstructive. Remnant cholesterol and triglyceriderich lipoproteins in. Jul 29, 20 we included individuals from the copenhagen general population study, a prospective population study. Risk factors for chronic cough among 14,669 individuals from. Fh initiative headlining the congress was the launch of the eas familial hypercholesterolaemia studies collaboration fhsc, a consortium of major fh registries across europe, asiapacific, africa and south america, led by professor kausik ray imperial college, london.
Below, the same research outputs are grouped by subject. Patients and methods we examined 86,975 individuals from the copenhagen general population study, recruited from 2003 through 2010. What is the abbreviation for copenhagen general population study. The aim of this study was to assess the potential relationship between volumetric thoracic bone mineral density and coronary calcification in a large population of men and women. Cgps abbreviation stands for copenhagen general population study.
We identified individuals with copd spirometrically. The copenhagen city heart study osterbroundersogelsen. The copenhagen general population study abstract send to citation mgr. We tested the hypothesis that high plasma glucose caused by genetic variation has a causal effect on the risk of unspecified dementia, alzheimers disease and vascular dementia in the general population. Major longlasting european studies of the general population this online supplement includes short summaries of largescale studies of the general population on the epidemiology of respiratory diseases and allergy that have been in progress for about 30 years or more and are still active. We included 5578 individuals aged 20100 years from the second examination of the copenhagen general population study cgps, a population based prospective cohort study initiated in april 2014 with ongoing enrolment. General population study cgps 20032007 exami nation 7 and the copenhagen city heart study. The first crosssectional survey on the general population sample of urban and suburban residents of pisa pi1 was performed in 19851988. The relationship between volumetric thoracic bone mineral.
Wheezing was selfreported, and asthma was ascertained through selfreport, hospital contacts with. Leukotriene c4 synthase and risk of cardiovascular. Design, setting, and participants this population based contemporary cohort study included 6292 patients with known ischemic heart disease ihd and 2277 with a previous myocardial infarction mi enrolled between november 2003 and february 2015. The copenhagen general population study was initiated in 2003 with ongoing enrollment. Impact of glucose level on micro and macrovascular disease. The copenhagen city heart study is a prospective study of the copenhagen general population initiated in 1976. The copenhagen city heart study is a prospective cardiovascular study of the danish general population initiated in 1976. Danish population study offers opportunity for discovery of blood biomarkers in individuals who suffer a heart attack without prior history of cardiovascular disease. Methods participants from the copenhagen general population study underwent multidetector computed tomography. The participants completed a questionnaire on health and lifestyle, were examined physically, had blood drawn for dna extraction, were tested for presence of chek21100delc using. The cchs provided the general population sample from denmark. Methods the study included 49,699 individuals from the copenhagen general population study and 10,8 individuals from the copenhagen city heart study with measurements of plasma lipoproteina, lpa kringleiv type 2 number of repeats, and lpa rs10455872. Pdf the copenhagen city heart study osterbroundersogelsen.
The current study population consisted of participants in a large population based study, inter99, which is reported in detail elsewhere 25, 39, 40. Hospital10 the copenhagen general population study, herlev hospital. Blood eosinophils and exacerbations in chronic obstructive. The highdensity lipoproteinadjusted score model worsens scorebased risk classification in a contemporary population of 30,824. Oct 09, 2015 the copenhagen city heart study, also known as osterbroundersogelsen, is a large prospective cardiovascular population study of 20,000 women and men that was launched in 1975 by dr peter schnohr and dr gorm jensen together with statistician jorgen nyboe and prof. Briefly, 61,301 individuals from a general population, aged 30 to 60 years and living in the southwestern part of copenhagen were randomly selected to participate in the study. Participation rates in general population studies in europe vary from 10% 15 to. Objective to study regulatory problems rps of feeding, sleeping and excessive crying in infancy, and explore the influence of maternal mental health problems and parentchild relationship problems. Mendelian randomisation studies have not shown a clear causal effect of high plasma glucose on the risk of alzheimers disease. Seroepidemiology of pertussis in a crosssectional study of an adult general population in denmark p.
In the copenhagen general population study, with 81,668 individuals, the corresponding value was 63 %. The copenhagen general population study the primary study cohort was comprised of 97 166 individuals from the prospective copenhagen general population study with baseline measurements of hdl cholesterol. Methods we genotyped 85 437 individuals aged 20100 years from the copenhagen general population study for fto rs9939609, mc4r rs177823, tmem18 rs6548238 gnpda2 rs10938397 and bdnf rs10767664. Original article majority of neversmokers with air. A random general population sample of 210 children from the copenhagen child birth cohort ccc 2000 was investigated by data from national danish registers and data collected prospectively from. Icosapent ethyl for the prevention of cardiovascular events. Future longitudinal studies should focus on possible risk factors for airflow limitation in this population. The copenhagen general population study, herlev and gentofte hospital, herlev, denmark.
Combined effect of pnpla3, tm6sf2, and hsd17b variants on. High risk of fatty liver disease amplifies the alanine. But perhaps, a headtohead comparison of remnant cholesterol with ldl cholesterol can be reported on in a followup publication, similar to what we have reported previously for individuals in the general population 15 and in patients with ischemic heart disease. The copenhagen general population study herlevosterbroundersogelsen 2008. Participants 95 766 white participants of danish descent from three cohorts, with median followup times. Rennard was particularly interested in estimating the sample size required for an intervention trial in individuals with early copd based on the outcomes used in our. Pdf predictors 010 months of psychopathology at age. Prevalence, characteristics, and prognosis of early chronic obstructive pulmonary disease. Ushapedrelationshipofhdlandrisk ofinfectiousdisease. The copenhagen general population study is supported by the copenhagen county foundation and herlev and gentofte hospital, copenhagen university hospital, denmark. New analysis from copenhagen general population study reaffirms. We recruited 94 079 individuals aged 20100 years from the copenhagen general population study, a prospective populationbased cohort study initiated in 2003 with ongoing enrolment.
The copenhagen general population study cgps is an ongoing prospective cohort study of the danish general population. Remnant cholesterol and myocardial infarction in normal weight, overweight, and obese individuals from. In the second examination, individuals are invited from the same. Hover over the donut graph to view the fc output for each subject. The copenhagen city heart study, bispebjerg and frederiksberg hospital, copenhagen, denmark. Jan 22, 2019 the current study population consisted of participants in a large population based study, inter99, which is reported in detail elsewhere 25, 39, 40.
Outcomes consequent to early copd for interventional studies. The copenhagen city heart study is an ongoing cardiovascular population study initiated in 1976 which has examined approximately 25,000 individuals from the general population. The table to the right includes counts of all research outputs for the copenhagen general population study published between 1 december 2018 30 november 2019 which are tracked by the nature index. Nationwide studies of idiopathic interstitial pneumonia and chronic obstructive pulmonary disease in the danish population. The initial sample has been reinvited up to four times and supplemented by younger individuals. All participants answered similar questionnaires, which. We studied participants in the copenhagen general population study, an ongoing cohort study initiated in 2003. Epidemiological studies of mental health problems in the first years of life are few. Jan 16, 2018 observational study of actual ascvd events during 10 years, followed by a modeling study to estimate the effectiveness of different guidelines. Lipoproteina and ischemic heart disease a causal association. Elevated lipoproteina and risk of ischemic stroke jacc.
Participants were selected randomly from the national civil registration system to represent the danish population aged 20100 years. Nordestgaard 2,3,4, marianne benn 2,3,4, luisa zuccolo 1, anne tybjaerghansen 2,3,5, and george davey smith 1. The authors thank the staff and participants of the copenhagen general population study and the copenhagen city heart study, and the participants of the metaanalyses of glucose and insulinrelated traits consortium magic, the ckdgen consortium, the uk biobank, and the cardiogramplusc4d consortium for their generous participation. We tested the hypothesis that individuals from the general population with high platelet count or high hematocrit have high risk of arterial and venous thrombosis. Comparison of major guidelines for statin use in primary. Design and setting data were collected in the general child health surveillance delivered to infant families by community health nurses chns. We included individuals from the copenhagen general population study, a prospective population study. Analyses were performed in the copenhagen general population study with a mean sd of 7. The copenhagen general population study cgps is a danish contemporary population based cohort study initiated in 2003 with ongoing enrollment. Obesity as a causal risk factor for aortic valve stenosis. In the present study we pooled data from two similar but independent studies. Characteristics and outcomes of chronic obstructive pulmonary.
Genetically low vitamin d concentrations and increased. The copenhagen general population study, denmark institution. So far, the main focus of studies using the copenhagen general population study has been genetic epidemiology, but we have also been focusing on. Problems of feeding, sleeping and excessive crying in infancy. The advantage of this approach in contrast to nested casecontrol studies is that the copenhagen general population study will contain an ever increasing amount of information on all participants allowing for detailed studies of risk factor interactions and in substrata of the general population. The copenhagen general population study, herlev and gentofte hospital, copenhagen university hospitals, copenhagen, denmark. Participants completed a selfadministered questionnaire concerning. The two sister studies in the copenhagen area include the copenhagen city heart study and. Major longlasting european studies of the general population. We prospectively followed 108 521 individuals from the copenhagen general population study for a median of 8 years. Setting copenhagen city heart study, copenhagen general population study, and copenhagen ischemic heart disease study.
Increased risk for other cancers in addition to breast cancer. Obese individuals experience wheezing without asthma but not. All individuals in denmark are assigned a unique identification number at birthimmigration that is recorded in the national danish civil registration system. The highdensity lipoproteinadjusted score model worsens. Risk factors for chronic cough in the general population have not been described systematically. Exploring causal associations between alcohol and coronary. Furthermore, diseasefree participants of the copenhagen general population study are very well suited to act as controls in casecontrol studies, where other research groups can provide cases. The population was grouped according to number of traditional risk factors and heart score was used to assess the risk of event for those with no cac, those with only cms 0 and those with both as and cms 0. The first 5592 included copenhagen general population study participants had lipoproteina total mass measured using a sensitive immunoturbidimetric assay from diasys diasys, diagnostic systems, holzheim, germany and the following participants in the copenhagen general population. This study aims to investigate infancy predictors of psychopathology in the second year of life.
Krogfelt1 1department of microbiology and infection control, statens serum institut, copenhagen denmark 2epidemiology research, statens serum institut, copenhagen denmark 3department of microbiology. A mendelian randomisation design was used with data. Methods study design and participants we included 5578 individuals aged 20100 years from the second examination of the copenhagen general population study cgps, a populationbased prospective cohort study initiated in april 2014 with ongoing enrolment. Platelet count and blood hematocrit were measured at. The participants completed a questionnaire before attending a physical examination including collection of whole blood for dna. Dec 15, 2016 the copenhagen city heart study is an ongoing cardiovascular population study initiated in 1976 which has examined approximately 25,000 individuals from the general population. In this prospective cohort study, we analysed data from 95 288 individuals aged 20100 years from the copenhagen general population study. Accaha guidelines superior to esceas guidelines for. Copenhagen general population study 2003 to 2006 examination and copenhagen city heart study 2001 to 2003 examination7 recruited participants randomly from the general population of copenhagen, denmark. In the present study, we compared the clinical performance of these two risk assessment models and evaluated the incremental predictive value of hdl cholesterol in an independent and contemporary european population, the copenhagen general population study cgps. Impact of glucose level on micro and macrovascular. We observed that individuals with chronic respiratory symptoms and normal spirometry had an increased risk of hospitalisations and death due to respiratory disease 1.
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